{"product_id":"proteintech-12961-1-ap","title":"Proteintech, 12961-1-AP, PPM1A Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe PPM1A (12961-1-AP) by Proteintech is a Polyclonal antibody targeting PPM1A in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n12961-1-AP targets PPM1A in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Jurkat cells, HepG2 cells,  human liver tissue,  rat kidney tissue,  mouse kidney tissue,  K-562 cells\nPositive IHC detected in: human breast cancer tissue, human urothelial carcinoma tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:8000\nImmunohistochemistry (IHC): IHC : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPPM1A(Protein phosphatase 1A) is also named as PPPM1A and belongs to the PP2C family. It is a serine\/threonine protein phosphatase that is essential for regulating cellular stress responses in eukaryotes. PPM1A plays an important role in tumor suppression and that it negatively controls many signaling pathways which are critical for trophoblast invasion.(PMID:19404668). This protein distributes in both the cytoplasm and nucleus of mammalian cells(PMID:9003755). It has 2 isoforms produced by alternative splicing.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag3645 Product name: Recombinant human PPM1A protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 49-383 aa of BC026691 Sequence: GLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW Predict reactive species\nFull Name: protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform\nCalculated Molecular Weight: 382 aa, 42 kDa\nObserved Molecular Weight: 42 kDa\nGenBank Accession Number: BC026691\nGene Symbol: PPM1A\nGene ID (NCBI): 5494\nRRID: AB_2169763\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P35813\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869489221801,"sku":"12961-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-12961-1-ap","provider":"Iright","version":"1.0","type":"link"}