{"product_id":"proteintech-13761-1-ap","title":"Proteintech, 13761-1-AP, CDK8\/19 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe CDK8\/19 (13761-1-AP) by Proteintech is a Polyclonal antibody targeting CDK8\/19 in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n13761-1-AP targets CDK8\/19 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Y79 cells, mouse brain tissue\nPositive IHC detected in: mouse testis tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:300-1:1000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe CDK8 homolog, CDK19 (Cdk11, CDC2L6) was discovered by Hidden Markov model (HMM) profiling of a eukaryotic protein kinase domain, and found to have approximately 91% sequence homology to Cdk8. The two proteins share a particularly high degree of sequence conservation in their kinase and cyclin binding domain (PMID: 30693281, 26985305). CDK8 and CDK19,  collectively termed 'Mediator Kinase,'  are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module. CDK8\/19 inhibition suppressed the induction of NFκB-driven transcription by p21 (PMID: 28855340).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag4731 Product name: Recombinant human CDC2L6 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-335 aa of BC037289 Sequence: MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF Predict reactive species\nFull Name: cell division cycle 2-like 6 (CDK8-like)\nCalculated Molecular Weight: 502 aa, 57 kDa\nObserved Molecular Weight: 50-57 kDa\nGenBank Accession Number: BC037289\nGene Symbol: CDK19\nGene ID (NCBI): 23097\nRRID: AB_2276048\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9BWU1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869523660969,"sku":"13761-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-13761-1-ap","provider":"Iright","version":"1.0","type":"link"}