{"product_id":"proteintech-15546-1-ap","title":"Proteintech, 15546-1-AP, VAMP8 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe VAMP8 (15546-1-AP) by Proteintech is a Polyclonal antibody targeting VAMP8 in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n15546-1-AP targets VAMP8 in WB, IHC, IF, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HL-60 cells, PC-12 cells,  THP-1 cells\nPositive IHC detected in: human placenta tissue, mouse placenta tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nVAMP8, also named endobrevin, is a member of the vesicle-associated membrane protein (VAMP)\/synaptobrevin family and the SNARE (soluble NSF-attachment protein receptor) superfamily. Characterized by a common sequence called the SNARE motif, SNARE proteins are involved in membrane fusion and vesicular transport (PMID: 11252968). VAMP8 is involved in autophagy by directly controlling the fusion of autophagosomes with the lysosomal membrane. It is required for dense-granule secretion in platelets and plays a role in regulated enzyme secretion in pancreatic acinar cells. VAMP8 is also involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag7903 Product name: Recombinant human VAMP8 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-81 aa of BC001634 Sequence: MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLIC Predict reactive species\nFull Name: vesicle-associated membrane protein 8 (endobrevin)\nCalculated Molecular Weight: 11 kDa\nObserved Molecular Weight: 15 kDa\nGenBank Accession Number: BC001634\nGene Symbol: VAMP8\nGene ID (NCBI): 8673\nRRID: AB_2878150\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9BV40\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868866728105,"sku":"15546-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-15546-1-ap","provider":"Iright","version":"1.0","type":"link"}