{"product_id":"proteintech-16168-1-ap","title":"Proteintech, 16168-1-AP, PSEN2-Specific Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe PSEN2-Specific (16168-1-AP) by Proteintech is a Polyclonal antibody targeting PSEN2-Specific in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n16168-1-AP targets PSEN2-Specific in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: C6 cells, A549 cells,  NIH\/3T3 cells\nPositive IHC detected in: human kidney tissue, human placenta tissue,  human colon tissue,  mouse brain tissue,  human breast cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:300-1:800\nImmunohistochemistry (IHC): IHC : 1:20-1:200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPresenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: presenilin 2 (Alzheimer disease 4)\nCalculated Molecular Weight: 50 kDa\nObserved Molecular Weight: 55-60 kDa\nGenBank Accession Number: NM_000447\nGene Symbol: PSEN2\nGene ID (NCBI): 5664\nRRID: AB_2170748\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P49810\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869577793705,"sku":"16168-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-16168-1-ap","provider":"Iright","version":"1.0","type":"link"}