{"product_id":"proteintech-17032-1-ap","title":"Proteintech, 17032-1-AP, GRK5 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe GRK5 (17032-1-AP) by Proteintech is a Polyclonal antibody targeting GRK5 in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n17032-1-AP targets GRK5 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, human skeletal muscle tissue,  HepG2 cells，mouse skeletal muscle tissue,  rat skeletal muscle tissue\nPositive IHC detected in: human skeletal muscle tissue, mouse heart tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nGRK5, also named as GPRK5, belongs to the protein kinase superfamily, AGC Ser\/Thr protein kinase family and GPRK subfamily. It is Serine\/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1\/MAPK3 signaling downstream of 5HT4-receptors. GRK5 is crucial for proper neuronal morphogenesis and the establishment of functional neuronal circuitry.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag10511 Product name: Recombinant human GRK5 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 186-590 aa of BC064506 Sequence: FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS Predict reactive species\nFull Name: G protein-coupled receptor kinase 5\nCalculated Molecular Weight: 590 aa, 68 kDa\nObserved Molecular Weight: 70 kDa\nGenBank Accession Number: BC064506\nGene Symbol: GRK5\nGene ID (NCBI): 2869\nRRID: AB_2115453\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P34947\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868912406697,"sku":"17032-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-17032-1-ap","provider":"Iright","version":"1.0","type":"link"}