{"product_id":"proteintech-17084-1-ap","title":"Proteintech, 17084-1-AP, RAI1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe RAI1 (17084-1-AP) by Proteintech is a Polyclonal antibody targeting RAI1 in WB, IHC, ELISA applications with reactivity to human samples\n17084-1-AP targets RAI1 in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells\nPositive IHC detected in: human stomach cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe RAI1 (Retinoic Acid Induced 1) gene is located on the short arm of chromosome 17. The RAI1 protein it encodes is a crucial transcriptional regulator, playing a central role in processes such as neurodevelopment, sleep regulation, circadian rhythms, and energy metabolism.\nThis protein contains a chromatin domain that binds to specific DNA sequences and recruits other transcriptional co-factors to activate or repress the expression of downstream target genes. The RAI1 gene is extremely sensitive to haploinsufficiency, and its dysfunction is closely linked to several severe neurodevelopmental disorders. For instance, RAI1 haploinsufficiency causes Smith-Magenis syndrome, while duplication of the RAI1 gene is associated with Potocki-Lupski syndrome. Consequently, the RAI1 protein is a key molecule for understanding brain function and behavioral regulation, and a major focus of research for related genetic syndromes.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag9046 Product name: Recombinant human RAI1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-350 aa of BC021209 Sequence: MQSFRERCGFHGKQQNYQQTSQETSRLENYRQPSQAGLSCDRQRLLAKDYYNPQPYPSYEGGAGTPSGTAAAVAADKYHRGSKALPTQQGLQGRPAFPGYGVQDSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRTHSLHVQQPPPPQQPLAYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTSSTYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSLAPGQRVQNLHAYQSGRLSYDQQQQQQQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQGYCQPDAAVRTPEQYYQTFSPSSSHSPARSV Predict reactive species\nFull Name: retinoic acid induced 1\nCalculated Molecular Weight: 1906aa,203 kDa; 966aa,104 kDa\nObserved Molecular Weight: 250-260 kDa\nGenBank Accession Number: BC021209\nGene Symbol: RAI1\nGene ID (NCBI): 10743\nRRID: AB_2284824\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q7Z5J4\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869748711593,"sku":"17084-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-17084-1-ap","provider":"Iright","version":"1.0","type":"link"}