{"product_id":"proteintech-17640-1-ap","title":"Proteintech, 17640-1-AP, SPCS3 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe SPCS3 (17640-1-AP) by Proteintech is a Polyclonal antibody targeting SPCS3 in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n17640-1-AP targets SPCS3 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, MG-63 cells,  U2OS cells,  mouse kidney tissue,  mouse liver tissue,  rat kidney tissue\nPositive IHC detected in: human placenta tissue, rat liver tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe microsomal signal peptidase complex (SPC), which is an essential membrane component in the endoplasmic reticulum (ER), has five subunits, including SEC11A, SEC11C, SPCS1, SPCS2, and SPCS3. Functionally, SPC removes signal peptides (SPs) from a series of secretory pre-proteins with high specificity. The dysregulation of the other SPC subunits was also observed in some tumors. SPCS3 expression can be used as a component of a risk score model to predict the survival of patients with pancreatic adenocarcinoma. (PMID: 35653344)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag11780 Product name: Recombinant human SPCS3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-180 aa of BC047290 Sequence: MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY Predict reactive species\nFull Name: signal peptidase complex subunit 3 homolog (S. cerevisiae)\nCalculated Molecular Weight: 180 aa, 20 kDa\nObserved Molecular Weight: 23 kDa\nGenBank Accession Number: BC047290\nGene Symbol: SPCS3\nGene ID (NCBI): 60559\nRRID: AB_3669279\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P61009\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887814201513,"sku":"17640-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-17640-1-ap","provider":"Iright","version":"1.0","type":"link"}