{"product_id":"proteintech-19540-1-ap","title":"Proteintech, 19540-1-AP, ZIP kinase Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe ZIP kinase (19540-1-AP) by Proteintech is a Polyclonal antibody targeting ZIP kinase in IHC, IF\/ICC, ELISA applications with reactivity to human, mouse, rat samples\n19540-1-AP targets ZIP kinase in IHC, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IHC detected in: human stomach cancer tissue, rat colon tissue,  rat heart tissue,  mouse colon tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: HeLa cells, U-251 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunohistochemistry (IHC): IHC : 1:250-1:1000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:20-1:200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nZipper-interacting protein (ZIP) kinase, also known as death-associated protein kinase 3 (DAPK3), is aserine\/threonine kinase that positively regulates mitochondrial-dependent apoptosis as well as autophagyand acts as a tumor suppressor.What is the molecular weight of ZIP kinase? Is ZIP kinase post-translationally modified?The molecular weight of ZIP kinase is 52 kDa. ZIP kinase contains seven phosphorylation sites (six threonineand one serine residues) that control its activity and localization (PMID: 24193917).What is the subcellular localization of ZIP kinase?ZIP kinase contains nuclear localization signal in its C-terminal part.ZIP kinase is present both in the cytoplasmand in the nucleus. In the cytoplasm ZIP kinase interacts with actin cytoskeleton, regulating contraction ofsmooth muscles (PMID: 16005610) and membrane blebbing (PMID: 11781833). In the nucleus it interactswith several transcription factors regulating gene expression.What is the tissue expression pattern of ZIP kinase?ZIP kinase is ubiquitously expressed.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: death-associated protein kinase 3\nCalculated Molecular Weight: 53 kDa\nObserved Molecular Weight: 37, 52 kDa\nGenBank Accession Number: NM_001348\nGene Symbol: DAPK3\nGene ID (NCBI): 1613\nRRID: AB_10860106\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: O43293\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887936786601,"sku":"19540-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-19540-1-ap","provider":"Iright","version":"1.0","type":"link"}