{"product_id":"proteintech-24287-1-ap","title":"Proteintech, 24287-1-AP, PDE11A Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe PDE11A (24287-1-AP) by Proteintech is a Polyclonal antibody targeting PDE11A in WB, ELISA applications with reactivity to human, mouse, rat samples\n24287-1-AP targets PDE11A in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse cerebellum tissue, mouse liver tissue,  rat liver tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPDE11A is a dual-specificity cyclic nucleotide phosphodiesterase that regulates cAMP and cGMP signaling in a tissue-restricted manner, with prominent roles in the endocrine system and brain. By shaping compartmentalized second-messenger signaling, PDE11A controls steroidogenesis, neuronal plasticity, and hormone responsiveness. Genetic alterations in PDE11A underlie adrenal hyperplasia, endocrine dysfunction, and neuropsychiatric phenotypes, highlighting its importance in cyclic nucleotide homeostasis.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag16495 Product name: Recombinant human PDE11A protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 582-934 aa of BC114431 Sequence: SYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSSPASVMVAKEDRN Predict reactive species\nFull Name: phosphodiesterase 11A\nCalculated Molecular Weight: 934 aa, 105 kDa\nObserved Molecular Weight: 66 kDa\nGenBank Accession Number: BC114431\nGene Symbol: PDE11A\nGene ID (NCBI): 50940\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9HCR9\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887754793129,"sku":"24287-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-24287-1-ap","provider":"Iright","version":"1.0","type":"link"}