{"product_id":"proteintech-26225-1-ap","title":"Proteintech, 26225-1-AP, PATZ1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe PATZ1 (26225-1-AP) by Proteintech is a Polyclonal antibody targeting PATZ1 in WB, ELISA applications with reactivity to human, mouse samples\n26225-1-AP targets PATZ1 in WB, IHC, ChIP, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse spleen tissue,  Raji cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPATZ1 (POZ\/BTB and AT-hook containing Zinc finger protein 1) is an important multifunctional transcriptional regulator. Its protein structure is distinctive, containing a POZ\/BTB domain (which mediates protein-protein interactions and transcriptional repression) and an AT-hook motif (which binds to AT-rich DNA sequences), as well as multiple C2H2-type zinc finger domains (responsible for sequence-specific DNA binding).  \n\nPATZ1 plays a \"double-edged sword\" role in regulating gene expression, capable of either activating or repressing target gene transcription depending on the co-regulators it interacts with and the cellular context. It plays a critical role in embryonic development and in the maintenance of stem cell pluripotency and differentiation. In recent years, its dual role in cancer has garnered significant attention. In various tumors (such as glioma, sarcoma, and colorectal cancer), PATZ1 can function as either an oncogene or a tumor suppressor depending on the context, participating in tumorigenesis and progression by influencing pathways such as the cell cycle, apoptosis, and the DNA damage response.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nCited Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag23912 Product name: Recombinant human PATZ1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-350 aa of BC021091 Sequence: MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSR Predict reactive species\nFull Name: POZ (BTB) and AT hook containing zinc finger 1\nObserved Molecular Weight: 70-74 kDa\nGenBank Accession Number: BC021091\nGene Symbol: PATZ1\nGene ID (NCBI): 23598\nRRID: AB_2880432\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9HBE1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869570388137,"sku":"26225-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-26225-1-ap","provider":"Iright","version":"1.0","type":"link"}