{"product_id":"proteintech-27243-1-ap","title":"Proteintech, 27243-1-AP, DSCR3 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe DSCR3 (27243-1-AP) by Proteintech is a Polyclonal antibody targeting DSCR3 in IP, ELISA applications with reactivity to human samples\n27243-1-AP targets DSCR3 in IP, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IP detected in: U-937 cells, SH-SY5Y cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate\n\u003cb\u003eBackground Information\u003c\/b\u003e\nDSCR3 (Down syndrome critical region protein 3) encodes VPS26C (Vacuolar protein sorting-associated protein 26C), a member of the retriever integral membrane protein recycling pathway. DSCR3 is a component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PMID: 31845315). DSCR3 specifically facilitates the transport of LRP1, but not of LDLR, from the endosomes to the plasma membrane, and hereby controls postprandial TG levels in plasma (PMID: 36353989, 35187626).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag23350 Product name: Recombinant human DSCR3 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-297 aa of BC110655 Sequence: MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI Predict reactive species\nFull Name: Down syndrome critical region gene 3\nObserved Molecular Weight: 30-33 kDa\nGenBank Accession Number: BC110655\nGene Symbol: DSCR3\nGene ID (NCBI): 10311\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: O14972\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887331299497,"sku":"27243-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-27243-1-ap","provider":"Iright","version":"1.0","type":"link"}