{"product_id":"proteintech-27265-1-ap","title":"Proteintech, 27265-1-AP, ATXN1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe ATXN1 (27265-1-AP) by Proteintech is a Polyclonal antibody targeting ATXN1 in WB, ELISA applications with reactivity to human, mouse, rat samples\n27265-1-AP targets ATXN1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse brain tissue, rat brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nAtaxin-1 (ATXN1) is a protein involved in transcriptional regulation and RNA binding. It is a transcriptional repressor that interacts with multiple transcription factors and is associated with large protein complexes. ATXN1 is also involved in the regulation of alternative splicing, as demonstrated by its ability to regulate the splicing of several minigenes. The protein is crucial for normal cerebellar function and is implicated in the pathogenesis of spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder caused by the expansion of a polyglutamine tract in ATXN1 (PMID: 21475249; 20628574).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag26099 Product name: Recombinant human ATXN1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 301-400 aa of NM_000332 Sequence: VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQA Predict reactive species\nFull Name: ataxin 1\nCalculated Molecular Weight: 87 kDa\nObserved Molecular Weight: 100 kDa\nGenBank Accession Number: NM_000332\nGene Symbol: ATXN1\nGene ID (NCBI): 6310\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P54253\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46885143183529,"sku":"27265-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-27265-1-ap","provider":"Iright","version":"1.0","type":"link"}