{"product_id":"proteintech-28136-1-ap","title":"Proteintech, 28136-1-AP, Caspase 14 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe Caspase 14 (28136-1-AP) by Proteintech is a Polyclonal antibody targeting Caspase 14 in WB, ELISA applications with reactivity to human, mouse, rat samples\n28136-1-AP targets Caspase 14 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse skin tissue, rat skin tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCaspase14 belongs to the caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspase14 exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits (p20 and p10) at Ile152\/Lys153 residues, which is different to other caspases (Asp residue). Caspase14 plays a role in protein maturation of filaggrin, and possibly in DNA repair. Overexpression of Caspase14 has been detected in several of epithelial malignancies, indicating that Caspase14 could play a role in carcinogenesis and disease progression of cancers. Caspase14 can binds the apoptosis-inducing factor (AIF) indicating that caspase14 may be an anti-apoptotic protein. In the LADC specimens, two bands can be detected with MW of 35 kDa and 37 kDa which represent Caspase14 and the phosphorylated Caspase14(pCasp-14) respectively. (PMID:21567094, 12200134, 10203698, 17515931, 16061209). This antibody can recognise all the forms of Caspase14.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag27242 Product name: Recombinant human CASP14 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-242 aa of BC069541 Sequence: MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ Predict reactive species\nFull Name: caspase 14, apoptosis-related cysteine peptidase\nCalculated Molecular Weight: 242 aa, 28 kDa\nObserved Molecular Weight: 35 kDa\nGenBank Accession Number: BC069541\nGene Symbol: CASP14\nGene ID (NCBI): 23581\nRRID: AB_3086031\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P31944\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46885841240233,"sku":"28136-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-28136-1-ap","provider":"Iright","version":"1.0","type":"link"}