{"product_id":"proteintech-28851-1-ap","title":"Proteintech, 28851-1-AP, Phospho-Neurofibromin 2 (Ser518) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-Neurofibromin 2 (Ser518) (28851-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-Neurofibromin 2 (Ser518) in WB, ELISA applications with reactivity to Human samples\n28851-1-AP targets Phospho-Neurofibromin 2 (Ser518) in WB, IHC, ELISA applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated HEK-293T cells, Calyculin A treated PC-3 cells,  HEK-293T cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:8000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nNeurofibromatosis 2 (NF2) tumor suppressor protein-merlin is involved in Hippo\/SWH signaling pathway that associated with tumor suppression by restricting proliferation and promoting apoptosis. It has been reported that merlin can change to phosphorylation form which inactivates merlin tumor suppressive abilities at serine 518 induced by Rac effector p21-activated kinase 2. The mutation of the NF2 tumor suppressor gene may lead to nervous system tumors, mesotheliomas and metastatic tumors. 28851-1-AP antibody is specific to phosphorylation of NF2 at serine 518. (PMID: 11782491, 14724586, 18361411, 18835652, 32115406)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: neurofibromin 2 (merlin)\nCalculated Molecular Weight: 70 kDa\nObserved Molecular Weight: 70 kDa\nGenBank Accession Number: BC007279\nGene Symbol: NF2\nGene ID (NCBI): 4771\nRRID: AB_2935410\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P35240\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869571666089,"sku":"28851-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-28851-1-ap","provider":"Iright","version":"1.0","type":"link"}