{"product_id":"proteintech-28853-1-ap","title":"Proteintech, 28853-1-AP, Phospho-Beta Catenin (Ser675) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-Beta Catenin (Ser675) (28853-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-Beta Catenin (Ser675) in WB, IF\/ICC, ELISA applications with reactivity to Human samples\n28853-1-AP targets Phospho-Beta Catenin (Ser675) in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: λ phosphatase treated HT-29 cells\nPositive IF\/ICC detected in: λ phosphatase treated MCF-7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:3000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nBeta Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. Beta catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt\/β-catenin signaling. Phosphorylation of Ser675  in the C-terminus of at beta catenin promotesmits nuclear accumulation and transcriptional activity, resulting in increased activation of the Wnt\/β-catenin signaling pathway(PMID: 25980439). In addition, Ser675 phosphorylation promotes beta catenin interaction with the transcriptional coactivator CREB-binding protein in the nucleus(PMID: 16476742).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nCited Reactivity: human, mouse, rat, bovine\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: catenin (cadherin-associated protein), beta 1, 88kDa\nCalculated Molecular Weight: 781 aa, 86 kDa\nObserved Molecular Weight: 90-100 kDa\nGenBank Accession Number: BC058926\nGene Symbol: Beta Catenin\nGene ID (NCBI): 1499\nENSEMBL Gene ID: ENSG00000168036\nRRID: AB_2923583\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P35222\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868898644137,"sku":"28853-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-28853-1-ap","provider":"Iright","version":"1.0","type":"link"}