{"product_id":"proteintech-29000-1-ap","title":"Proteintech, 29000-1-AP, Phospho-TSC2 (Thr1462) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-TSC2 (Thr1462) (29000-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-TSC2 (Thr1462) in WB, ELISA applications with reactivity to Human, Mouse samples\n29000-1-AP targets Phospho-TSC2 (Thr1462) in WB, ELISA applications and shows reactivity with Human, Mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: PDGF treated PC-3 cells, PDGF treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTSC2, also named as Tuberin, plays an essential role in the cellular energy response pathway. TSC2 forms a physical and functional complex with TSC1 that can inhibit the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It has been reported that TSC2 can be phosphorylated at Thr1462 by Akt\/PKB involved in stimulating cell growth and is activated by insulin. (PMID: 14651849, 12172553)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, Mouse\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: tuberous sclerosis 2\nCalculated Molecular Weight: 1807 aa, 201 kDa\nObserved Molecular Weight: 200 kDa\nGenBank Accession Number: BC150300\nGene Symbol: TSC2\nGene ID (NCBI): 7249\nRRID: AB_2918227\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P49815\nStorage Buffer: PBS with 0.02% sodium azide, 50% glycerol, and 0.05% BSA, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869730033833,"sku":"29000-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-29000-1-ap","provider":"Iright","version":"1.0","type":"link"}