{"product_id":"proteintech-29107-1-ap","title":"Proteintech, 29107-1-AP, Phospho-PKN1 (Thr774) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-PKN1 (Thr774) (29107-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-PKN1 (Thr774) in WB, ELISA applications with reactivity to Human, mouse samples\n29107-1-AP targets Phospho-PKN1 (Thr774) in WB, ELISA applications and shows reactivity with Human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: PDGF treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPKN1 is a stress-responsive kinase and a member of the protein kinase novel (PKN) family also known as protein kinase C-related kinases (PRKs). PKN1 acting downstream of small GTP-binding proteins of the Rho\/Rac family. The interaction of Rho with PKN1 induces a conformational change in PKN1 leading to activation loop phosphorylation by PDK1 on Thr774 in the case of human PKN1 (Thr778 in mouse\/rat) which is necessary for the catalytic activation of PKN1\/2 and critical for the stability of the protein. (PMID: 29045568, PMID: 21037231)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: protein kinase N1\nCalculated Molecular Weight: 942 aa, 104 kDa\nObserved Molecular Weight: 130 kDa\nGenBank Accession Number: BC040061\nGene Symbol: PKN1\nGene ID (NCBI): 5585\nRRID: AB_2918235\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q16512\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887760920745,"sku":"29107-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-29107-1-ap","provider":"Iright","version":"1.0","type":"link"}