{"product_id":"proteintech-31352-1-ap","title":"Proteintech, 31352-1-AP, Phospho-FRS2 (Tyr436) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-FRS2 (Tyr436) (31352-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-FRS2 (Tyr436) in WB, ELISA applications with reactivity to human, mouse samples\n31352-1-AP targets Phospho-FRS2 (Tyr436) in WB, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: bFGF treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nFibroblast growth factor substrate 2 (FRS2), a lipid-anchored docking protein that is phosphorylated upon activation of FGFR, is critical for recruitment of downstream signaling molecules and links the FGFRs to the Ras\/Mek\/Erk pathway and the PI3-Kinase\/Akt pathway. Studies have found that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc, suggesting a model in which competitive binding between FRS-2 and Shc regulates differentiation versusproliferation. (PMID: 19053057, PMID: 10092678)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: fibroblast growth factor receptor substrate 2\nCalculated Molecular Weight: 60 kDa\nObserved Molecular Weight: 80-85 kDa\nGenBank Accession Number: BC021562\nGene Symbol: FRS2\nGene ID (NCBI): 10818\nRRID: AB_3669956\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q8WU20\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887759839401,"sku":"31352-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-31352-1-ap","provider":"Iright","version":"1.0","type":"link"}