{"product_id":"proteintech-32467-1-ap","title":"Proteintech, 32467-1-AP, KIAA1024 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe KIAA1024 (32467-1-AP) by Proteintech is a Polyclonal antibody targeting KIAA1024 in WB, ELISA applications with reactivity to human, rat samples\n32467-1-AP targets KIAA1024 in WB, ELISA applications and shows reactivity with human, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: rat brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nKIAA1024 negatively regulates the activities of mTORC1 and mTORC2 by stabilizing the MTOR complex inhibitor DEPTOR, thus inhibiting cell overgrowth. In cultured hippocampal neurons and PC12 cells, knocking down KIAA1024 can activate mTOR signal and promote neurite outgrowth. However, in zebrafish and mouse transplanted tumor models, deletion of this gene will significantly enhance the tumor formation induced by HRAS(G12V), suggesting that it has antitumor effect.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag38274 Product name: Recombinant human KIAA1024 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 742-891 aa of NM_015206.2 Sequence: VGLNEEEIKDTGPGDNKDWHRKSKEADRQYDIPPQHRLPKQPKDGFLVEQVFSPHPYPASLKAHMKSNPLYTDMRLTELAEVKRGQPSWTIEEYARNAGDKGKLTALDLQTQESLNPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKVCK Predict reactive species\nFull Name: KIAA1024\nCalculated Molecular Weight: 103kDa，916aa\nObserved Molecular Weight: 102 kDa\nGenBank Accession Number: NM_015206.2\nGene Symbol: KIAA1024\nGene ID (NCBI): 23251\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity Purification\nUNIPROT ID: Q9UPX6\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887695220905,"sku":"32467-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-32467-1-ap","provider":"Iright","version":"1.0","type":"link"}