{"product_id":"proteintech-32874-1-ap","title":"Proteintech, 32874-1-AP, TXNDC15 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe TXNDC15 (32874-1-AP) by Proteintech is a Polyclonal antibody targeting TXNDC15 in WB, IHC, ELISA applications with reactivity to human samples\n32874-1-AP targets TXNDC15 in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, MCF-7 cells,  RKO cells,  fetal human brain tissue\nPositive IHC detected in: human ovary cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\nImmunohistochemistry (IHC): IHC : 1:300-1:1200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTXNDC15 (thioredoxin domain-containing protein 15) is a single-pass type I transmembrane protein that contains a thioredoxin domain and is primarily localized in the cytoplasm. It plays a positive regulatory role in the Hedgehog signaling pathway within cilia and actively participates in the process of ciliogenesis, exerting significant influence on the structure and function of cilia-an essential cellular organelle. Additionally, TXNDC15 has been found to form mixed disulfide complexes with endoplasmic reticulum-resident protein disulfide isomerase (PDI) family members, such as ERp57, PDI, and ERp44, suggesting its involvement in protein folding and quality control processes. Notably, mutations in the TXNDC15 gene are associated with a rare and lethal genetic disorder known as Meckel-Gruber syndrome, which is caused by defects in ciliogenesis.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag37138 Product name: Recombinant human TXNDC15 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 33-321 aa of BC032568 Sequence: VEVAEESGRLWSEEQPAHPLQVGAVYLGEEELLHDPMGQDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKS Predict reactive species\nFull Name: thioredoxin domain containing 15\nObserved Molecular Weight: 55 kDa\nGenBank Accession Number: BC032568\nGene Symbol: TXNDC15\nGene ID (NCBI): 79770\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity Purification\nUNIPROT ID: Q96J42\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887911948457,"sku":"32874-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-32874-1-ap","provider":"Iright","version":"1.0","type":"link"}