{"product_id":"proteintech-55139-1-ap","title":"Proteintech, 55139-1-AP, ARHGAP10 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe ARHGAP10 (55139-1-AP) by Proteintech is a Polyclonal antibody targeting ARHGAP10 in WB, IHC, ELISA applications with reactivity to human,   mouse samples\n55139-1-AP targets ARHGAP10 in WB, IHC, ELISA applications and shows reactivity with human,   mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse heart tissue,  HEK-293 cells,  human heart tissue,  mouse kidney tissue\nPositive IHC detected in: human heart tissue,  human skeletal muscle tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nARHGAP10, also named as GRAF2, is GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. It is essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. ARHGAP10 inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. It stabilizes PAK-2p34 thereby increasing stimulation of cell death. The antibody is specific to ARHGAP10.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nCited Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: Rho GTPase activating protein 10\nCalculated Molecular Weight: 89 kDa\nObserved Molecular Weight: 89 kDa\nGenBank Accession Number: NM_024605\nGene Symbol: ARHGAP10\nGene ID (NCBI): 79658\nRRID: AB_10794449\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: A1A4S6\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868915585193,"sku":"55139-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-55139-1-ap","provider":"Iright","version":"1.0","type":"link"}