{"product_id":"proteintech-65102-1-ig","title":"Proteintech, 65102-1-Ig, Anti-Mouse GITR\/TNFRSF18 (DTA-1)","description":"Size: 100ug \/ 500ug\nThe GITR\/TNFRSF18 (65102-1-Ig) by Proteintech is a Monoclonal antibody targeting GITR\/TNFRSF18 in FC applications with reactivity to mouse samples\n65102-1-Ig targets GITR\/TNFRSF18 in FC applications and shows reactivity with mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: mouse splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nGlucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse\nHost \/ Isotype: Rat \/ IgG2b, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Mouse CD25+ CD4+ T cells Predict reactive species\nFull Name: tumor necrosis factor receptor superfamily, member 18\nGenBank Accession Number: BC146517\nGene Symbol: CD357\nGene ID (NCBI): 21936\nRRID: AB_2918402\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Affinity purification\nUNIPROT ID: O35714\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888097480873,"sku":"65102-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-65102-1-ig","provider":"Iright","version":"1.0","type":"link"}