{"product_id":"proteintech-65205-1-ig","title":"Proteintech, 65205-1-Ig, Anti-Mouse CD8a (5H10-1)","description":"Size: 100ug \/ 500ug\nThe CD8a (65205-1-Ig) by Proteintech is a Monoclonal antibody targeting CD8a in IF-P, FC applications with reactivity to mouse samples\n65205-1-Ig targets CD8a in IF-P, FC applications and shows reactivity with mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IF-P detected in: mouse spleen tissue\nPositive FC detected in: mouse splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunofluorescence (IF)-P: IF-P : 1:400-1:1600\nFlow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-\/CD8+ T cells (PMID: 1968084).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse\nHost \/ Isotype: Rat \/ IgG2b, lambda\nClass: Monoclonal\nType: Antibody\nImmunogen: Concanavalin A-stimulated BALB\/c splenic T cells Predict reactive species\nFull Name: CD8 antigen, alpha chain\nGenBank Accession Number: BC030679\nGene Symbol: Cd8a\nGene ID (NCBI): 12525\nRRID: AB_3084904\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: P01731\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888097120425,"sku":"65205-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-65205-1-ig","provider":"Iright","version":"1.0","type":"link"}