{"product_id":"proteintech-65283-1-ig","title":"Proteintech, 65283-1-Ig, Anti-Human M-CSF (3G12E6)","description":"Size: 100ug\nThe M-CSF (65283-1-Ig) by Proteintech is a Monoclonal antibody targeting M-CSF in FC (Intra) applications with reactivity to human samples\n65283-1-Ig targets M-CSF in FC (Intra) applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC (Intra) detected in: LPS, TNF-α and Brefeldin A treated human PBMCs\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC) (INTRA): FC (INTRA) :\n\u003cb\u003eBackground Information\u003c\/b\u003e\nM-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration and plays a role in lipoprotein clearance (PMID: 29734839; 29679908; 28202039)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: Recombinant protein Predict reactive species\nFull Name: colony stimulating factor 1 (macrophage)\nCalculated Molecular Weight: 60 kDa\nGenBank Accession Number: BC021117\nGene Symbol: M-CSF\nGene ID (NCBI): 1435\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: P09603\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888095711401,"sku":"65283-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-65283-1-ig","provider":"Iright","version":"1.0","type":"link"}