{"product_id":"proteintech-67355-1-ig","title":"Proteintech, 67355-1-Ig, P27; KIP1 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe P27; KIP1 (67355-1-Ig) by Proteintech is a Monoclonal antibody targeting P27; KIP1 in WB, ELISA applications with reactivity to Human, mouse, rat samples\n67355-1-Ig targets P27; KIP1 in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Jurkat cells, K-562 cells,  HSC-T6 cells,  NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nDKN1B, also named as P27 or KIP1, is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A\/p21. P27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controlling cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Downregulation of P27 has been implicated in the progression of several malignancies, including lung cancer, hepatocellular carcinoma, salivary cancer, oral squamous cell carcinomas, and gastric cancer.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, mouse, rat\nCited Reactivity: human, mouse\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag14634 Product name: Recombinant human P27; KIP1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-198 aa of BC001971 Sequence: MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT Predict reactive species\nFull Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)\nCalculated Molecular Weight: 198 aa, 22 kDa\nObserved Molecular Weight: 27 kDa\nGenBank Accession Number: BC001971\nGene Symbol: p27 Kip1\/CDKN1B\nGene ID (NCBI): 1027\nRRID: AB_2882610\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: P46527\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888022311081,"sku":"67355-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-67355-1-ig","provider":"Iright","version":"1.0","type":"link"}