{"product_id":"proteintech-69518-1-ig","title":"Proteintech, 69518-1-Ig, NeutraControl IL-10 Mouse McAb","description":"Size: 100ug\nThe NeutraControl IL-10 (69518-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraControl IL-10 in ELISA, Non-Neutralization applications with reactivity to Human samples\n69518-1-Ig targets  IL-10 in WB, ELISA, Non-Neutralization applications and shows reactivity with Human samples.\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.This antibody is a neutralizing control antibody for IL-10,  the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nCited Reactivity: mouse\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Product name: HumanKine® recombinant human IL-10 protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species\nFull Name: interleukin 10\nGene Symbol: IL-10\nGene ID (NCBI): 3586\nRRID: AB_2918852\nConjugate: Unconjugated\nForm: Lyophilized Powder\nPurification Method: Protein G purification\nUNIPROT ID: P22301\nStorage Buffer: Sterile PBS, pH 7.4.\nEndotoxin: \u0026lt;0.1 EU\/μg\nReconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg\/mL in sterile H2O before use.\nStability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888046559401,"sku":"69518-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-69518-1-ig","provider":"Iright","version":"1.0","type":"link"}