{"product_id":"proteintech-80064-2-rr","title":"Proteintech, 80064-2-RR, Phospho-MEK6 (Ser207) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-MEK6 (Ser207) (80064-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-MEK6 (Ser207) in WB, ELISA applications with reactivity to human, mouse samples\n80064-2-RR targets Phospho-MEK6 (Ser207) in WB, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: UV treated HEK-293 cells, HeLa cells,  UV NIH\/3T3 cells,  UV treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMAPKK6 (Dual specificity mitogen activated protein kinase kinase 6), also known as MAP2K6 \/ MEK6 \/ MKK6, is a member of MAPKK protein kinase family. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase. MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. Phosphorylation of Ser207 and Thr211 by MAP3Ks is critical for MEK6 activation, and acetylation of these resides by VopA blocks MEK6 activity(PMID: 26648936). Because the polypeptide sequence near the Ser218 site of MEK3 is very similar to the Ser207 site of MEK6, this antibody also detects the phosphorylated at Ser218 of the MEK3, which is located at Ser189 in the isoform2 of MEK3.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: mitogen-activated protein kinase kinase 6\nCalculated Molecular Weight: 334 aa, 37 kDa\nObserved Molecular Weight: 38 kDa, 40kDa\nGenBank Accession Number: BC012009\nGene Symbol: MEK6\nGene ID (NCBI): 5608\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P52564\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888803205289,"sku":"80064-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-80064-2-rr","provider":"Iright","version":"1.0","type":"link"}