{"product_id":"proteintech-80488-1-rr","title":"Proteintech, 80488-1-RR, Beta Catenin Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Beta Catenin (80488-1-RR) by Proteintech is a Recombinant antibody targeting Beta Catenin in WB, IHC, IF\/ICC, ELISA, ChIP-qPCR applications with reactivity to human, mouse, rat, pig, zebrafish samples\n80488-1-RR targets Beta Catenin in WB, IHC, IF\/ICC, CoIP, ELISA, ChIP-qPCR applications and shows reactivity with human, mouse, rat, pig, zebrafish samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A431 cells, zebrafish tissue,  HeLa cells,  HEK-293 cells,  MCF-7 cells,  LNCaP cells,  HSC-T6 cells,  NIH\/3T3 cells,  4T1 cells,  pig brain tissue\nPositive IHC detected in: human liver cancer tissue, human breast cancer tissue,  human colon cancer tissue,  human rectal cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: MCF-7 cells\nPositive ChIP-qPCR detected in: HCT 116 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunohistochemistry (IHC): IHC : 1:1000-1:4000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:1000-1:4000\nCHIP-QPCR: CHIP-QPCR : 1:10-1:100\n\u003cb\u003eBackground Information\u003c\/b\u003e\nβ-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt\/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat, pig, zebrafish\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: catenin (cadherin-associated protein), beta 1, 88kDa\nCalculated Molecular Weight: 781 aa, 86 kDa\nObserved Molecular Weight: 92 kDa\nGenBank Accession Number: BC058926\nGene Symbol: Beta Catenin\nGene ID (NCBI): 1499\nENSEMBL Gene ID: ENSG00000168036\nRRID: AB_2918895\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P35222\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888363917481,"sku":"80488-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-80488-1-rr","provider":"Iright","version":"1.0","type":"link"}