{"product_id":"proteintech-80553-2-rr","title":"Proteintech, 80553-2-RR, Phospho-TSC2 (Ser1387) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-TSC2 (Ser1387) (80553-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-TSC2 (Ser1387) in WB, FC (Intra), ELISA applications with reactivity to human, mouse samples\n80553-2-RR targets Phospho-TSC2 (Ser1387) in WB, FC (Intra), ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated NIH\/3T3 cells, NIH\/3T3 cells\nPositive FC (Intra) detected in: Calyculin A treated HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTSC2, also named as Tuberin, plays an essential role in the cellular energy response pathway. TSC2 forms a physical and functional complex with TSC1 that can inhibit the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. AMPK can phosphorylate and activate the Ser1387 site of TSC2.(PMID: 14651849, 12172553, PMID: 23244622)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: tuberous sclerosis 2\nCalculated Molecular Weight: 1807 aa, 201 kDa\nObserved Molecular Weight: 200 kDa\nGenBank Accession Number: BC150300\nGene Symbol: TSC2\nGene ID (NCBI): 7249\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P49815\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888805040297,"sku":"80553-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-80553-2-rr","provider":"Iright","version":"1.0","type":"link"}