{"product_id":"proteintech-80698-1-rr","title":"Proteintech, 80698-1-RR, Phospho-TSC2 (Thr1462) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-TSC2 (Thr1462) (80698-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-TSC2 (Thr1462) in WB, ELISA applications with reactivity to human, mouse samples\n80698-1-RR targets Phospho-TSC2 (Thr1462) in WB, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated HEK-293 cells, Calyculin A treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTSC2, also named Tuberin, plays an essential role in the cellular energy response pathway. TSC2 forms a physical and functional complex with TSC1 that can inhibit the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It has been reported that TSC2 can be phosphorylated at Thr1462 by Akt\/PKB involved in stimulating cell growth and is activated by insulin. (PMID: 14651849, 12172553)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: tuberous sclerosis 2\nCalculated Molecular Weight: 1807 aa, 201 kDa\nObserved Molecular Weight: 200 kDa\nGenBank Accession Number: BC150300\nGene Symbol: TSC2\nGene ID (NCBI): 7249\nRRID: AB_3085354\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P49815\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888658043049,"sku":"80698-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-80698-1-rr","provider":"Iright","version":"1.0","type":"link"}