{"product_id":"proteintech-81767-2-rr","title":"Proteintech, 81767-2-RR, Phospho-ZAP70 (Tyr319)\/SYK (Tyr352) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-ZAP70 (Tyr319)\/SYK (Tyr352) (81767-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-ZAP70 (Tyr319)\/SYK (Tyr352) in WB, ELISA applications with reactivity to human samples\n81767-2-RR targets Phospho-ZAP70 (Tyr319)\/SYK (Tyr352) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: H2O2 treated Jurkat cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nZeta-associated protein (ZAP)-70, a member of the Syk family of tyrosine kinases, plays an important role in T-cell receptor signaling, natural killer (NK) cell activation and early B-cell development. Three tyrosine residues (Tyr292, Tyr315 and Tyr319) in the interdomain B region of ZAP‐70 have attracted particular attention as sites that might regulate ZAP‐70 activity and\/or binding to heterologous proteins.  The third candidate phosphorylation site in the interdomain B region of ZAP‐70 is Tyr319.  Although the functional importance of this site in ZAP‐70 is unknown, a previous report presented indirect evidence that the orthologous Tyr352 residue in Syk is involved in the association of PLC‐γ1 with this PTK. (PMID: 10202147)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: zeta-chain (TCR) associated protein kinase 70kDa\nCalculated Molecular Weight: 70 kDa\nObserved Molecular Weight: 70 kDa, 72kDa\nGenBank Accession Number: BC039039\nGene Symbol: ZAP70\nGene ID (NCBI): 7535\nENSEMBL Gene ID: ENSG00000115085\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P43403\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888805236905,"sku":"81767-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-81767-2-rr","provider":"Iright","version":"1.0","type":"link"}