{"product_id":"proteintech-82636-2-rr","title":"Proteintech, 82636-2-RR, RUNX2 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe RUNX2 (82636-2-RR) by Proteintech is a Recombinant antibody targeting RUNX2 in WB, IP, ELISA, ChIP-qPCR applications with reactivity to human, mouse samples\n82636-2-RR targets RUNX2 in WB, IHC, IF, IP, CoIP, ELISA, ChIP-qPCR applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: PC-3 cells, Saos-2 cells,  C2C12 cells\nPositive IP detected in: ROS1728 cells\nPositive ChIP-qPCR detected in: Saos-2 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nImmunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate\nCHIP-QPCR: CHIP-QPCR : 1:10-1:100\n\u003cb\u003eBackground Information\u003c\/b\u003e\nRUNX2, also named as AML3, CBFA1, OSF2 and PEBP2A, is a Transcription factor which involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters By similarity. RUNX2 inhibits MYST4-dependent transcriptional activation.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: runt-related transcription factor 2\nCalculated Molecular Weight: 57 kDa\nObserved Molecular Weight: 57-60 kDa\nGenBank Accession Number: NM_004348\nGene Symbol: RUNX2\nGene ID (NCBI): 860\nRRID: AB_3086495\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q13950\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888346976425,"sku":"82636-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-82636-2-rr","provider":"Iright","version":"1.0","type":"link"}