{"product_id":"proteintech-83331-1-rr","title":"Proteintech, 83331-1-RR, Phospho-SYK (Tyr323) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-SYK (Tyr323) (83331-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-SYK (Tyr323) in WB, IF\/ICC, ELISA applications with reactivity to Human samples\n83331-1-RR targets Phospho-SYK (Tyr323) in WB, IF\/ICC, ELISA applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: pervanadate treated Ramos cells\nPositive IF\/ICC detected in: pervanadate treated Ramos cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:125-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. The study found that in human platelets,  inhibition of PKC leads to Syk hyperphosphorylation on residues Tyr-525\/526 whereas Tyr-323 and Tyr-352 phosphorylations are unaffected.  PKC negatively regulates Syk activity, as evidenced by hyperphosphorylation of downstream targets, LAT and PLCγ2 upon PKC inhibition. (PMID: 23960082)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: spleen tyrosine kinase\nCalculated Molecular Weight: 72 kDa\nObserved Molecular Weight: 70 kDa\nGenBank Accession Number: BC001645\nGene Symbol: SYK\nGene ID (NCBI): 6850\nENSEMBL Gene ID: ENSG00000165025\nRRID: AB_3670995\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: P43405\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888439152809,"sku":"83331-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-83331-1-rr","provider":"Iright","version":"1.0","type":"link"}