Proteintech, 83938-3-RR, TIMP2 Recombinant monoclonal antibody

Size: 20ul / 100ul The TIMP2 (83938-3-RR) by Proteintech is a Recombinant antibody targeting TIMP2 in WB, ELISA applications with reactivity to human samples 83938-3-RR targets TIMP2 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: A549 cells, HT-1080 cells, HeLa cells Recommended dilution Western Blot (WB): WB : 1:2000-1:10000 Background Information The TIMPs are natural highly specific endogenous inhibitors of MMPs. Human TIMP family consists of four 21-28 kDa proteins known as TIMP1, TIMP2, TIMP3, and TIMP4 encoded by four paralogous genes.TIMPs are vital to the maintenance of ECM homeostasis primarily through their MMP inhibitory functions. TIMP2, a member of the TIMP family, regulates the proteolytic activity of all MMPs and is involved in cell differentiation, growth, migration, angiogenesis, and apoptosis. Urinary TIMP2 has been recently recognized as an early biomarker to predict Acute kidney injury (AKI) in critically ill patients. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg0430 Product name: Recombinant Human TIMP2 protein (His Tag) Source: mammalian cells -derived, pHZ-KIsec-C-6*HIS Tag: C-6*HIS Domain: 27-220 aa of BC052605 Sequence: CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP Predict reactive species Full Name: TIMP metallopeptidase inhibitor 2 Calculated Molecular Weight: 220 aa, 24 kDa Observed Molecular Weight: 21-24 kDa GenBank Accession Number: BC052605 Gene Symbol: TIMP2 Gene ID (NCBI): 7077 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P16035 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.