{"product_id":"proteintech-84723-3-rr","title":"Proteintech, 84723-3-RR, Tyrosinase Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Tyrosinase (84723-3-RR) by Proteintech is a Recombinant antibody targeting Tyrosinase in WB, ELISA applications with reactivity to human samples\n84723-3-RR targets Tyrosinase in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A549 cells, A375 cells,  L02 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTyrosinase is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.  It's a melanocyte-specific enzyme critical for the synthesis of melanin, a process normally restricted to a post-Golgi compartment termed the melanosome. Loss-of-function mutations in tyrosinase are the cause of oculocutaneous albinism. The 60-kDa tyrosinase core polypeptide is modified in the endoplasmic reticulum (ER) by cotranslational addition of multiple N-linked glycans, producing the 70-kDa species. Complex sugar modifications in the Golgi apparatus further increases tyrosinase's molecular mass to 80 kDa, the size of the mature wild-type (WT) isoform. (PMID:10823941)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag34940 Product name: Recombinant human Tyrosinase protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 19-200 aa of BC027179 Sequence: HFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDF Predict reactive species\nFull Name: tyrosinase (oculocutaneous albinism IA)\nCalculated Molecular Weight: 529 aa, 60 kDa\nObserved Molecular Weight: 80 kDa\nGenBank Accession Number: BC027179\nGene Symbol: TYR\nGene ID (NCBI): 7299\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: P14679\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888838332585,"sku":"84723-3-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-84723-3-rr","provider":"Iright","version":"1.0","type":"link"}