{"product_id":"proteintech-85104-3-rr","title":"Proteintech, 85104-3-RR, Cleaved Caspase 10\/P23 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Cleaved Caspase 10\/P23 (85104-3-RR) by Proteintech is a Recombinant antibody targeting Cleaved Caspase 10\/P23 in WB, ELISA applications with reactivity to human samples\n85104-3-RR targets Cleaved Caspase 10\/P23 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Staurosporine treated Jurkat cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1\/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: caspase 10, apoptosis-related cysteine peptidase\nCalculated Molecular Weight: 59 kDa\nObserved Molecular Weight: 23 kDa\nGenBank Accession Number: BC042844\nGene Symbol: Caspase 10\nGene ID (NCBI): 843\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: Q92851\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888726757545,"sku":"85104-3-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-85104-3-rr","provider":"Iright","version":"1.0","type":"link"}