{"product_id":"proteintech-85171-3-rr","title":"Proteintech, 85171-3-RR, Cleaved Caspase 8\/P18 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Cleaved Caspase 8\/P18 (85171-3-RR) by Proteintech is a Recombinant antibody targeting Cleaved Caspase 8\/P18 in WB, IHC, ELISA applications with reactivity to human samples\n85171-3-RR targets Cleaved Caspase 8\/P18 in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Staurosporine treated Jurkat cells\nPositive IHC detected in: Jurkat cellsNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunohistochemistry (IHC): IHC : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCASP8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. CASP8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion\/caspase-9 pathway (PMID:19194987). This antibody recognize the cleaved caspase 8.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: caspase 8, apoptosis-related cysteine peptidase\nCalculated Molecular Weight: 538 aa, 62 kDa\nObserved Molecular Weight: 55 kDa, 18 kDa\nGenBank Accession Number: BC028223\nGene Symbol: Caspase 8\nGene ID (NCBI): 841\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q14790\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888727085225,"sku":"85171-3-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-85171-3-rr","provider":"Iright","version":"1.0","type":"link"}