{"product_id":"proteintech-86376-1-rr","title":"Proteintech, 86376-1-RR, G-CSF Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe G-CSF (86376-1-RR) by Proteintech is a Recombinant antibody targeting G-CSF in WB, IF\/ICC, FC (Intra), ELISA applications with reactivity to human samples\n86376-1-RR targets G-CSF in WB, IF\/ICC, FC (Intra), ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, HepG2 cells,  K-562 cells,  MCF-7 cells,  MOLT-4 cells,  A549 cells\nPositive IF\/ICC detected in: K-562 cells\nPositive FC (Intra) detected in: K-562 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nGranulocyte colony-stimulating factor (G-CSF), also referred to as CSF3, is a protective cytokine with anti-inflammatory effects. G-CSF is important in promoting survival of the granulocytic lineage cells and proliferation and migration of neutrophils as well as trophoblast cells. G-CSF acts by binding to its receptor G-CSFR (also called CSF3R), which after binding with G-CSF activates the canonical Janus kinase (Jak)\/signal transducer, activator of transcription (STAT)and Ras\/Raf\/MAP kinase pathways. G-CSF potently stimulates the proliferation and release of peripheral blood progenitor cells into the bloodstream and is therefore used to treat neutropenia after chemotherapy. Furthermore, G-CSF levels are elevated upon intensive exercise leading to increased neutrophil counts, which are predominantly due to delayed neutrophil apoptosis.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Product name: HumanKine® recombinant human G-CSF protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species\nFull Name: colony stimulating factor 3 (granulocyte)\nObserved Molecular Weight: 20 kDa\nGene Symbol: G-CSF\nGene ID (NCBI): 1440\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P09919\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888638218409,"sku":"86376-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-86376-1-rr","provider":"Iright","version":"1.0","type":"link"}