{"product_id":"proteintech-86641-1-rr","title":"Proteintech, 86641-1-RR, Phospho-STAT6 (Tyr641) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-STAT6 (Tyr641) (86641-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-STAT6 (Tyr641) in WB, FC (Intra), ELISA applications with reactivity to human samples\n86641-1-RR targets Phospho-STAT6 (Tyr641) in WB, FC (Intra), ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: IL-4 treated ACHN cells\nPositive FC (Intra) detected in: IL-4 treated ACHN cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSTAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. p-STAT6(Tyr641) is a biomarker of Th2-high inflammation, targeted by IL-4Rα blockers (dupilumab) and JAK1\/3 inhibitors. High p-STAT6 in TAMs correlates with M2 polarization and radioresistance, blocking IL-4 or JAK1\/3 decreases Tyr641 phosphorylation and restores anti-tumor immunity. (PMID: 37474750)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: signal transducer and activator of transcription 6, interleukin-4 induced\nCalculated Molecular Weight: 100 kDa\nObserved Molecular Weight: 110 kDa\nGenBank Accession Number: BC005823\nGene Symbol: STAT6\nGene ID (NCBI): 6778\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P42226\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888656699561,"sku":"86641-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-86641-1-rr","provider":"Iright","version":"1.0","type":"link"}