{"product_id":"proteintech-87096-1-rr","title":"Proteintech, 87096-1-RR, Phospho-HER2\/ErbB2 (Tyr1248) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-HER2\/ErbB2 (Tyr1248) (87096-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-HER2\/ErbB2 (Tyr1248) in WB, ELISA applications with reactivity to human samples\n87096-1-RR targets Phospho-HER2\/ErbB2 (Tyr1248) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: human Neuregulin-1 treated T-47D cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nHER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Phospho-HER2\/ErbB2 (Tyr1248) is a phosphorylated form of the HER2 protein, which is a member of the epidermal growth factor receptor (EGFR) family. This phosphorylation event is considered a prerequisite for HER2 signaling and its transforming activity. The phosphorylation of HER2 at Tyr1248 residue is a key step in the activation of downstream signaling cascades that regulate various cellular processes, including cell growth, proliferation, and survival. Tyrosine 1248 is the main autophosphorylation site in the carboxy terminal domain of ErbB2 linked to downstream signaling through the ras-raf-MEK-p42\/44 MAPK signal transduction pathway. (PMID: 19084911)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog (avian)\nCalculated Molecular Weight: 1255 aa, 138 kDa\nObserved Molecular Weight: 185 kDa\nGenBank Accession Number: BC156755\nGene Symbol: HER2\/ErbB2\nGene ID (NCBI): 2064\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P04626\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888801763497,"sku":"87096-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87096-1-rr","provider":"Iright","version":"1.0","type":"link"}