{"product_id":"proteintech-87205-1-rr","title":"Proteintech, 87205-1-RR, Phospho-HER2\/ErbB2 (Tyr1196) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-HER2\/ErbB2 (Tyr1196) (87205-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-HER2\/ErbB2 (Tyr1196) in WB, ELISA applications with reactivity to human samples\n87205-1-RR targets Phospho-HER2\/ErbB2 (Tyr1196) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: human Neuregulin-1 treated T-47D cells, human Neuregulin-1 treated MCF-7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nHER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Phospho-HER2\/ErbB2 (Tyr1196) is a phosphorylated form of the HER2 protein, which is a receptor tyrosine kinase that plays a critical role in cell growth, proliferation, and survival. The phosphorylation of HER2 at Tyr1196 is associated with the activation of downstream signaling pathways. In breast cancer, HER2 is overexpressed and contributes to aggressive tumor growth and poor prognosis. Overexpression of Her2\/ErbB2\/Neu in cancer is often correlated with recurrent distant metastasis, although the mechanism still remains largely elusive. Tyr1139\/Tyr1196 are autonomously phosphorylated, when Her2 is overexpressed. (PMID: 21966491)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog (avian)\nCalculated Molecular Weight: 1255 aa, 138 kDa\nObserved Molecular Weight: 185 kDa\nGenBank Accession Number: NM_004448\nGene Symbol: HER2\/ErbB2\nGene ID (NCBI): 2064\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P04626\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888801697961,"sku":"87205-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87205-1-rr","provider":"Iright","version":"1.0","type":"link"}