{"product_id":"proteintech-87268-1-rr","title":"Proteintech, 87268-1-RR, Phospho-c-MYC (Thr58) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-c-MYC (Thr58) (87268-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-c-MYC (Thr58) in WB, ELISA applications with reactivity to human samples\n87268-1-RR targets Phospho-c-MYC (Thr58) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: MG132 treated HEK-293T cells, MG132 treated HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMYC is a transcription factor that globally enhances expression of transcribing genes, including those vital for cell cycle, growth, proliferation, and survival in normal and cancer cells. MYC has multiple isomers, and this antibody recognizes the phosphorylation of the 439 amino acid isomer (P01106-1, UniProt) at the 62 serine site. Posttranslational modifications that regulate MYC stability include phosphorylations at Ser62 and Thr58. Phosphorylation at Ser62, primarily by ERK, stabilizes MYC. While kinases other than ERK phosphorylate Ser62, GSK3β has been the only kinase known to phosphorylate MYC at Thr58.(PMID: 32482868)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: v-myc myelocytomatosis viral oncogene homolog (avian)\nCalculated Molecular Weight: 49 kDa\nObserved Molecular Weight: 55-60 kDa\nGenBank Accession Number: BC000141\nGene Symbol: MYC\nGene ID (NCBI): 4609\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P01106\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888800354473,"sku":"87268-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87268-1-rr","provider":"Iright","version":"1.0","type":"link"}