{"product_id":"proteintech-87269-1-rr","title":"Proteintech, 87269-1-RR, STK3\/MST2 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe STK3\/MST2 (87269-1-RR) by Proteintech is a Recombinant antibody targeting STK3\/MST2 in WB, ELISA applications with reactivity to human samples\n87269-1-RR targets STK3\/MST2 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe protein encoded by STK3 gene is a key serine\/threonine kinase, and its protein product can be cleaved by caspase in the process of apoptosis, and the inhibitory C-terminal part is removed, and the N-terminal part is transferred to the nucleus to form homodimer, which becomes an active kinase and promotes chromatin condensation in the process of apoptosis. STK3 is one of the core components of Hippo signaling pathway, which plays a key role in controlling cell proliferation, apoptosis and tissue growth. In the Hippo signaling pathway, STK3 forms a cascade reaction with STK4, LATS1\/2 and other kinases, phosphorylates and activates LATS1\/2, and then inhibits transcription coactivators YAP and TAZ, thus controlling cell growth and preventing cancer progression. STK3 and STK4(MST1) are similar in structure and function. They have conserved amino-terminal kinase domains, carboxyl-terminal regulatory domains and interaction domains.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag2741 Product name: Recombinant human STK3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-306 aa of BC010640 Sequence: MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQ Predict reactive species\nFull Name: serine\/threonine kinase 3 (STE20 homolog, yeast)\nCalculated Molecular Weight: 491 aa, 56 kDa\nObserved Molecular Weight: 56-63 kDa\nGenBank Accession Number: BC010640\nGene Symbol: STK3\nGene ID (NCBI): 6788\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q13188\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888828076201,"sku":"87269-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87269-1-rr","provider":"Iright","version":"1.0","type":"link"}