{"product_id":"proteintech-87312-1-rr","title":"Proteintech, 87312-1-RR, Phospho-P53 (Ser33) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-P53 (Ser33) (87312-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-P53 (Ser33) in WB, ELISA applications with reactivity to human samples\n87312-1-RR targets Phospho-P53 (Ser33) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: etoposide treated T-47D cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTP53, also known as P53 and NY-CO-13, belongs to the p53 family and has 9 isoforms. In SDS-Page, the observed molecular weight is about 53 kDa. Phosphorylation of p53 at specific amino acid residues plays a crucial role in mediating its various functions, including its role as a transcription factor that regulates the expression of genes involved in the cellular response to stress and DNA damage. Upon severe DNA damage, p53 is phosphorylated at specific amino acid residues, becomes stabilized, and activated to induce apoptosis-related genes. To date, 10 kinases have been identified to phosphorylate p53 for apoptosis at specific serine\/threonine residues in the N- and C-terminus domains. (PMID: 30191640)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: tumor protein p53\nCalculated Molecular Weight: 44 kDa\nObserved Molecular Weight: 53 kDa\nGenBank Accession Number: NM_000546\nGene Symbol: P53\nGene ID (NCBI): 7157\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P04637\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888803467433,"sku":"87312-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87312-1-rr","provider":"Iright","version":"1.0","type":"link"}