{"product_id":"proteintech-87525-1-rr","title":"Proteintech, 87525-1-RR, Phospho-PFKFB2 (Ser483) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-PFKFB2 (Ser483) (87525-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-PFKFB2 (Ser483) in WB, ELISA applications with reactivity to human samples\n87525-1-RR targets Phospho-PFKFB2 (Ser483) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: IGF-1 treated MCF-7 cells, HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPhospho-PFKFB2 (Ser483) is the active-site-switching modification of the heart-type bifunctional enzyme 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase (PFKFB2). Phosphorylation at serine 483, located in the C-terminal regulatory segment, is catalyzed mainly by Akt downstream of PI3K and is essential for maximal 2-kinase activity: it increases the synthesis of fructose-2,6-bisphosphate (F2,6BP), the most potent allosteric activator of 6-phosphofructo-1-kinase (PFK-1), thereby accelerating glycolytic flux and ATP production. (PMID: 34282152)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: 6-phosphofructo-2-kinase\/fructose-2,6-biphosphatase 2\nCalculated Molecular Weight: 58 kDa\nObserved Molecular Weight: 55 kDa\nGenBank Accession Number: NM_006212\nGene Symbol: PFKFB2\nGene ID (NCBI): 5208\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: O60825\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888803991721,"sku":"87525-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-87525-1-rr","provider":"Iright","version":"1.0","type":"link"}