Proteintech, 98116-1-RR, Anti-Human Neprilysin/CD10 Rabbit Recombinant Antibody

Size: 100ug The Neprilysin/CD10 (98116-1-RR) by Proteintech is a Recombinant antibody targeting Neprilysin/CD10 in FC applications with reactivity to human samples 98116-1-RR targets Neprilysin/CD10 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood leukocytes, Reh cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD10, also known as neprilysin, membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), or common acute lymphoblastic leukemia antigen (CALLA), is a 100-kDa type II transmembrane glycoprotein belonging to peptidase M13 family (PMID: 7760013; 8102558). Among hematopoietic cells, CD10 is expressed on granulocytes, B cell precursors, mature germinal center B cells, a subset of immature thymocytes (PMID: 13679451). CD10 is also expressed on a variety of nonhematopoietic cell types, including bronchial epithelial cells, cultured fibroblasts, bone marrow stromal cells, renal proximal tubular epithelial cells, breast myoepithelium, biliary canaliculi (PMID: 8102558). CD10 is a cell surface peptidase that cleaves peptide bonds on the amino side of hydrophobic amino acids and inactivates a variety of physiologically active peptides. Loss or decreases in CD10 expression have been reported in a variety of malignancies (PMID: 16054017). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: membrane metallo-endopeptidase Calculated Molecular Weight: 750 aa, 86 kDa GenBank Accession Number: BC101658 Gene Symbol: CD10 Gene ID (NCBI): 4311 RRID: AB_3672263 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P08473 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.