{"product_id":"proteintech-cl555-tmt","title":"Proteintech, CL555-tmt, ChromoTek anti-TIM3 recombinant VHH, CoraLite® Plus 555","description":"Size: 150ul\nCL555-tmt targets TIM3  in FC and IF applications and shows reactivity with Human samples.\n\u003cb\u003eSpecification\u003c\/b\u003e\nApplications: FC, IF\nReactivity: Human\nConjugate: CoraLite® Plus 555\nType: Nanobody\nClass: Recombinant\nHost: Alpaca\nAffinity: Picomolar range, below the assay limit (biolayer interferometry)\nMolecular Weight: 14.824 kDa\nForm: Liquid\nExcitation\/Emission Maxima Wavelengths: 554 nm \/ 570 nm\nRRID: AB_3101921\nStorage Buffer: 500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide\nStorage Condition: Store at -20°C; Shipped at ambient temperature.\nBackground: TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 (PMID: 20107545; 17069754; 11725301).","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888879915177,"sku":"CL555-tmt","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-cl555-tmt","provider":"Iright","version":"1.0","type":"link"}