{"product_id":"proteintech-cl647-65083","title":"Proteintech, CL647-65083, CoraLite® Plus 647 Anti-Human CD80 (2D10.4)","description":"Size: 100tests\nThe CD80 (CL647-65083) by Proteintech is a Monoclonal antibody targeting CD80 in FC applications with reactivity to human samples\nCL647-65083 targets CD80 in FC applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: Daudi cells, IFN-γ and LPS-stimulated THP-1-derived macrophages\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 5 ul per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: N\/A Predict reactive species\nFull Name: CD80 molecule\nCalculated Molecular Weight: 33 kDa\nGenBank Accession Number: BC042665\nGene Symbol: CD80\nGene ID (NCBI): 941\nRRID: AB_2883670\nConjugate: CoraLite® Plus 647 Fluorescent Dye\nExcitation\/Emission Maxima Wavelengths: 654 nm \/ 674 nm\nForm: Liquid\nPurification Method: Affinity purification\nUNIPROT ID: P33681\nStorage Buffer: PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.\nStorage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888094793897,"sku":"CL647-65083","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-cl647-65083","provider":"Iright","version":"1.0","type":"link"}