{"product_id":"proteintech-pe-fca98139","title":"Proteintech, PE-FcA98139, FcZero-rAb™ PE Anti-Human TRAIL\/CD253 Rabbit Recombinant Antibody","description":"Size: 100tests\nThe TRAIL\/CD253 (PE-FcA98139) by Proteintech is a Recombinant antibody targeting TRAIL\/CD253 in FC applications with reactivity to human samples\nPE-FcA98139 targets TRAIL\/CD253 in FC applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: IFN-a treated human PBMCs\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 5 ul per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTRAIL, also known as CD253 or TNFSF10 (tumor necrosis factor superfamily member 10), is a typical death ligand expressed on natural killer cells and cytotoxic T lymphocytes. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL induces apoptotic cell death in cancer by binding to its functional death receptors, death receptor (DR) 4 (TNFRSF10A\/TRAIL-R1) and DR5 (TNFRSF10B\/TRAIL-R2) to activate the extrinsic apoptosis pathway. TRAIL also activates c-Jun N-terminal kinase (MAPK8\/JNK) and the transcription factor nuclear factor-κB (NFκB). The binding of this protein to its receptors has been shown to trigger the activation of MAPK8\/JNK, caspase 8, and caspase 3.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Recombinant Protein Predict reactive species\nFull Name: tumor necrosis factor (ligand) superfamily, member 10\nCalculated Molecular Weight: 281 aa, 33 kDa\nGenBank Accession Number: BC032722\nGene Symbol: TRAIL\nGene ID (NCBI): 8743\nConjugate: PE Fluorescent Dye\nExcitation\/Emission Maxima Wavelengths: 496 nm, 565 nm \/ 578 nm\nExcitation Laser: Blue Laser (488 nm), Green Laser (532 nm), Yellow-Green Laser (561 nm)\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P50591\nStorage Buffer: PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.\nStorage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888627175593,"sku":"PE-FcA98139","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/proteintech-pe-fca98139","provider":"Iright","version":"1.0","type":"link"}