Agilent, 5190-2454, Agilent Bio WCX, NP10, 4 x 10 mm, guard

Agilent Bio WCX, NP10, 4 x 10 mm, guard. A weak cation exchange HPLC guard column with nonporous particles. Particle size is 10 μm. Nonporous particles are best for efficient mass transfer and high resolution separations.

Specifications:
Brand: Agilent Bio WCX
Column Material: Stainless Steel
Guard Column: Yes
Hardware: SS
Inner Diameter (ID): 4 mm
LC Platform: Stainless Steel
Length: 10 mm
Maximum Temperature: 80 °C
Part Number Application Domain: Biopharma
Part Number Application: Charge Variant AnalysisPeptidesProteins
Particle Size: 10 µm
Particle Type: Non-porous
Phase: WCX
Pressure Rating: 275 bar
Separation Mode: Ion Exchange (IEX)
Shipping Solvent: Phosphate Buffer
Technique: LC
UNSPSC Code: 41115711
pH Range: 2-12

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This strong cation exchange guard cartridge is designed to protect and extend the life of analytical columns during the separation and analysis of biomolecules such as peptides and proteins. It features a 4 x 10 mm format with NP10 stationary phase, ensuring minimal sample loss and consistent performance for high-throughput laboratories. The proprietary weak cation exchange chemistry offers effective retention and resolution of charged species under native conditions, making it ideal for quality control, pharmaceutical research, and proteomics workflows.

Engineered for compatibility with Agilent's bio-inert HPLC and UHPLC systems, the guard integrates seamlessly with larger analytical columns, including those in the Bio WCX NP10 series. Its robust construction allows for repeated use in demanding laboratory environments, reducing downtime and costs associated with column replacements. The cartridge effectively captures particulates and contaminants from complex biological samples, preserving column integrity and sample fidelity.

Suitable for method development, validation, and routine analysis, this guard is frequently employed in biopharmaceutical characterization, charge variant profiling, and monoclonal antibody analysis. A vital accessory for researchers seeking reproducible and high-quality results, it is optimized to function with Agilent’s biochromatography systems and is recommended for use alongside matching analytical columns for best performance.